LGSOC is a rare tumor subtype with high case fatality rates in patients with metastatic disease. Here, we use multiomics integration of whole-exome sequencing, RNA sequencing, and mass spectrometry–based proteomics on LGSOC cell lines to elucidate novel biomarkers and therapeutic vulnerabilities.
Delighted to share our paper describing an algorithm CONETT to identify Conserved Evolutionary Trajectory Tree from multiple tumors. This paper will be presented at the #ISMB2020 conference next week. @cenksahinalp https://t.co/9uMAoaPDoQ pic.twitter.com/uV1NO23tDe
— Raunak Shrestha (@raunakms) July 15, 2020
The PCAWG Project, conducted by the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes, employed comprehensive whole genome sequencing and integrated analysis techniques on more than 2,600 primary cancers and their corresponding normal tissues from 38 different tumor types.
Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer originating from the abdominal lining. Our study revealed that BAP1 could serve as a prognostic and predictive biomarker for immunotherapy in PeM.
We introduce a novel combinatorial method, cd-CAP, for simultaneous detection of connected subnetworks of an interaction network where genes exhibit conserved alteration patterns across tumor samples.
An algorithm to identify cancer driver genes in individual cancer patients by measuring the influence of gene alterations on perturbing transcriptional networks.