We discovered a group of metastatic prostate cancer patients with lower levels of DNA-DNA interactions around the Androgen Receptor (AR) gene, the main driver of prostate cancer. Interestingly, this group had an abundance of circular DNA outside of the chromosomes (extrachromosomal circular DNA (ecDNA)) that included parts of the AR gene resulting in AR gene amplification and become very active, which might explain why their cancer was resistant to treatment.