Cancer

The PCAWG Project, conducted by the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes, employed comprehensive whole genome sequencing and integrated analysis techniques on more than 2,600 primary cancers and their corresponding normal tissues from 38 different tumor types.

Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer originating from the abdominal lining. Our study revealed that BAP1 could serve as a prognostic and predictive biomarker for immunotherapy in PeM.

We introduce a novel combinatorial method, cd-CAP, for simultaneous detection of connected subnetworks of an interaction network where genes exhibit conserved alteration patterns across tumor samples.

An algorithm to identify cancer driver genes in individual cancer patients by measuring the influence of gene alterations on perturbing transcriptional networks.